Zinc-Catalyzed Selective Reduction of Cyclic Imides with Hydrosilanes: Synthesis of omega-Hydroxylactams
关键字：cyclic imides; diamine ligands; hydrosilylation; omega-hydroxylactams; zinc catalysis
摘要：Cyclic imides were selectively reduced to the corresponding omega-hydroxylactams in high yields with (EtO)(3)SiH (triethoxysilane) or PMHS (polymethylhydrosiloxane) under catalysis of zinc diacetate dehydrate [Zn(OAc)(2)center dot 2H(2)O] (10%) and tetramethylethylenediamine (TMEDA) (10%). This catalytic protocol showed good functional group tolerance as well as excellent regioselectivity for unsymmetrical imides bearing coordinating groups adjacent to the carbonyl.
卷号：357
期号：5
是否译文：否
