Piezo-Augmented and Photocatalytic Nanozyme Integrated Microneedles for Antibacterial and Anti-Inflammatory Combination Therapy

Key Words:HYDROGEN-SULFIDE; NITRIC-OXIDE; INFLAMMATION; MECHANISMS; RESOLUTION

Abstract:Wound infection is arguably the most common, and potentially the most devastating, complication of the wound healing process. The ideal treatment strategy has to eliminate bacteria, alleviate inflammation, and promote wound healing and skin formation. Herein, a multifunctional heterostructure is designed consisting of ultrasmall platinum-ruthenium nanoalloys and porous graphitic carbon nitride C3N5 nanosheets (denoted as PtRu/C3N5), which concurrently possesses piezoelectric enhanced oxidase -mimic nanozyme activity and photocatalytic hydrogen gas production capacity. Moreover, these hybrid nanotherapeutics are integrated in natural hyaluronic acid microneedles, which exhibit almost 100% broad-spectrum antibacterial efficacy against multiple bacterial strains in vitro and in vivo within 10 min ultrasound treatment, and effectively inhibit inflammation reactions after 1 h visible light irradiation, promising for accelerating the cutaneous wound healing in the bacterial infected mice. This work highlights a competitive strategy for development of all-in-one antibacterial and anti-inflammatory therapies.

Volume:33

Issue:10

Translation or Not:no