关键字：NANOCOMPOSITES; NANOPARTICLES; NANOZYMES; FE
摘要：In this study, a novel organic photophotochemical transistor (OPECT) biosensing platform was proposed for dualmode detection of CEA. The dual-mode detecting system is achieved benefit from the exceptional photoelectric performance of MIL-53(Fe) -NH2@ZnIn2S4 (MNZ) and the peroxidase enzyme (POD) activity of ZIF-67/ Cu0.76Co2.24O4 (ZIF-67/CuCoO). Ab2- ZIF-67/CuCoO probe was immobilized on a 96-well plate by enzymelinked immunosorbent assay, which accelerated the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) by hydrogen peroxide and thus successfully realized visual detection of CEA. Additionally, in OPECT biosensing mode, the oxidized form of TMB (oxTMB & sdot;) serves as a consumptive agents of the electron donor AA, which cause the photocurrent change of MNZ heterojunction, leading to a decrease in the channel current of poly (ethylenedioxythiophene): poly (styrene sulfonate) (PEDOT: PSS) organic transistor. The integration of nanobiocatalysts and the OPECT system demonstrates excellent detection performance for CEA, with a detection limit as low as 3.24 fg mL- 1 and expanded their prospective applications for clinical detection of nucleic acids, proteins, and other tumor markers.
卷号：268
期号：-
是否译文：否