周现锋

教授

教授 博士生导师

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所在单位:材料科学与工程学院

学历:博士研究生

办公地点:四方校区CCE大楼1003

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A photostable triphenylamine-based flavonoid dye: Solvatochromism, aggregation-induced emission enhancement, fabrication of organic nanodots, and cell imaging applications

发布时间:2021-03-15 点击次数:

关键字:Fluorescent dyes; Aggregation-induced emission; enhancement; Flavonoid; Photostability; Bioimaging
摘要:Fluorescent organic nanodots are considered as the promising tools for long-term cellular imaging, due to their high luminescence, good photostability and good biocompatibility. In this study, a novel triphenylamine-based flavonoid dye with aggregation-induced emission enhancement characteristics was designed and synthesized. Based on these flavonoid dyes, the organic nanodots were facilely fabricated without further surface modification, exhibiting the low cytotoxicity, good resistance against photobleaching, and acceptable cell uptake. Remarkably, these nanodots achieved a long-term bioimaging for living cells with 70% of their initial fluorescence retained after 48 h continuously incubation. The excellent properties made the flavonoid dye the promising addition to the current library of fluorescent organic nanodots in bioimaging application. (C) 2017 Elsevier Ltd. All rights reserved.
卷号:142
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