关键字：Crystallization ；Liquid–liquid phase separation ；Phase diagram ；Seeding ；Supersaturation control

摘要：Liquid–liquidphaseseparation(LLPS)duringcrystallizationdevelopmentofpharmaceu-ticalsisbeingreportedincreasinglyinrecentyears.Itoftencausesqualityissuessuchasfailureofimpurityrejectandfragilemorphology.Inworstcases,crystallizationcan-notproceedatallafterLLPSoccurs.ManystudieshavebeenpublishedonLLPSduringcrystallizationandananalysisandsynthesisofthecurrentstate-of-artisneeded.Inthisreview,recentadvancesinLLPSresearchwillbesummarized,includingbrieftheoreticalinterpretationsofLLPS,characteristicsinphasediagramsandmeasurementmethodsforrepresentativemodelsystems,strategiestosuppressLLPS,crystallizationdevelopmentinthepresenceofLLPSandoptionswhendirectcrystallizationfailsduetoLLPS.ThisreviewaimstoprovideaframeworktodealwiththeoccurrenceofLLPSduringcrystallizationdevelopment

卷号：174

期号：0

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