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1-环己氧基-4-羟基-2,2,6,6-四甲基哌啶醇的合成

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  • Key Words:1-环己氧基-4-羟基-2,2,6,6-四甲基哌啶醇;;4-羟基-2,2,6,6-四甲基哌啶氮氧自由基;;环己烷;;O-烷基化反应

  • Abstract:对以4-羟基-2,2,6,6-四甲基哌啶氮氧自由基(ZJ-701)和环己烷为原料,叔丁基过氧化氢为氧化剂,CuCl_2·2H_2O为催化剂,通过O-烷基化反应合成1-环己氧基-4-羟基-2,2,6,6-四甲基哌啶醇进行了研究。结果表明,较佳反应条件为:n(ZJ-701)∶n(TBHP)∶n(CuCl_2)∶n(环己烷)∶n(乙醇)=1∶9.6∶0.25∶13∶35,反应时间为9h,反应温度约65℃,较理想的提纯工艺为硼氢化物还原-减压蒸馏-重结晶。在以上条件下,目标产物的含量为98.49%,分离产率为52.0%。该工艺反应条件温和,产品含量及收率较高。

  • Volume:v.39;No.173

  • Issue:04

  • Translation or Not:no

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