Synthesis, structure characterization, and biological evaluation of some new 1,2,3-benzotriazole derivatives

• Key Words:Benzotriazole compounds; Antimycotic activities; Antitumor activities; Crystal structure
• Abstract:Ten novel benzotriazole compounds were synthesized. Their chemical structures were confirmed by (1)H NMR, IR, and elemental analyses, coupled with three selected single-crystal structures (compounds A2, B3, and B5). Their antimycotic and antitumor activities were also investigated. The title compounds showed some antitumor activities, especially in the case of A3 and A4, which showed the most potent activity of propagation inhibition in liver and galactophore cancer cells.
• Volume:19
• Issue:8
• Translation or Not:no