Release time:2023-10-19  Hits:

• Key Words:IN-VIVO; SELECTIVE DETECTION; GLUTATHIONE; INFLAMMATION; MECHANISMS; APOPTOSIS; DISEASES
• Abstract:There is an urgent need to develop highly sensitive and selective fluorescence probes for ONOO- in mitochondria. Herein, we reported a ratiometric fluorescent probe COUS with coumarin-cyanine hybrid as fluorophore and C = C bonds as reaction sites of ONOO- . The probe COUS was sensitive and selective to ONOO-, and had a large fluorescence emission shift (239 nm) as well as a low detection limit (41.88 nM). Moreover, COUS showed the mitochondrial targeting ability, and the targeting moiety could dissociate from the probe when reacting with ONOO-, which enabled COUS to accurately detect ONOO- in mitochondria.
• Volume:292
• Issue:
• Translation or Not:no