王鲲鹏   Associate professor

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The coumarin-pyrazole dye for detection of hydrogen sulfide in cells

Release time:2023-10-19  Hits:

  • Key Words:INFRARED FLUORESCENT-PROBE; LARGE STOKES SHIFT; LIVING CELLS; BIOIMAGING APPLICATION; SELECTIVE DETECTION; H2S; FOOD
  • Abstract:Fluorescent probes for H2S are often interfered by other thiols. In this work, a coumarin-pyrazole dye with 2,4-dinitrosulfonyl group was designed for the detection of H2S. The probe exhibits weak fluorescence in water due to the photo induced electron transfer (PET) by 2,4-dinitrosulfonyl. After the sulfonyl group is cleaved off by H2S, strong fluorescence appears. The probe can specifically detect H2S without being interfered by other biological thiols, and shows a wide applicable pH range, low detection and wide detection range. The excellent detection properties of the probe can also be used to detect endogenous and exogenous H2S in cells. In addition, the probes can be made into portable test paper for the detection of H2S in solutions and can detect H2S in different water samples.
  • Volume:285
  • Issue:
  • Translation or Not:no