王鲲鹏   Associate professor

No content

Recommended MA Supervisor
Paper Publications Current position: Home > Scientific Research > Paper Publications

Enhancing probe's sensitivity for peroxynitrite through alkoxy modification of dicyanovinylchromene

Release time:2023-10-19  Hits:

  • Key Words:FLUORESCENT-PROBE; PI-CONJUGATION; CONSTRUCTION; MITOCHONDRIA; LIVER; PH
  • Abstract:An intramolecular charge transfer (ICT)-based fluorescent probe P-ONOO- was synthesized to detect ONOO-. After responding to peroxynitrite, the dicyano-vinyl group of P-ONOO- generates the aldehyde group, emitting strong green fluorescence accompanied by quenching of the yellow fluorescence. According to the calculated Fukui function, the modification of the alkoxy group can enhance the f( ) of P-ONOO-, which can enhance the probe's nucleophilic addition reactivity with ONOO-. It has been experimentally verified that P-ONOO- shows fast response (within 30 s), excellent sensitivity (the detection limit = 10.4 nM), and good selectivity towards ONOO-. Additionally, the probe P-ONOO- has high membrane permeability and good biocompatibility, which can image endogenous ONOO- and exogenous ONOO- in HeLa cells.
  • Volume:414
  • Issue:23
  • Translation or Not:no
Pre One: Efficient deep blue emi by 4-styrylbenzonitrile derivatives in solid state: Synthesis, aggregation induced emi characteristics and crystal structures & nbsp;</p>
Next One: Artificial light-harvesting systems based on self-assembled fluorescent palladium(II)-metallacycle in aqueous solution

Click: | The Last Update Time:-- | Open time:-- | MOBILE Version

Laoshan Campus-99 Songling Road, Qingdao City, Shandong Province
Sifang Campus-No.53 Zhengzhou Road, Qingdao City, Shandong Province
Sino-German International Cooperation Zone (Sino-German Campus)-No. 3698 Tuanjie Road, West Coast New District, Qingdao City, Shandong Province
Gaomi Campus-No. 1 Xingtan West Street, Gaomi City, Shandong Province
Jinan Campus-No. 80 Wenhua East Road, Jinan City, Shandong Province ©2015 Qingdao University of Science and Technology
Administrator email: master@qust.e