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摘要：(Hydroxyl camptothecin@sodium cholate)-layered double hydroxide (LDH) nanohybrids were prepared by a modified drug-coassembly method. Firstly, Hydroxyl camptothecin (HCPT) was incorporated into micelles derived from sodium cholate (SCL) which negatively charged. The negatively charged micelles intercalated HCPT@SCL-LDH nanohybrids were prepared by a co-assembly between LDH nanosheets and sodium cholate micelles with the encapsulated HCPT could keep the biological active lactone form, and the drug loading ::H:of:H:: so-obtained nanohybrid was 12.9%. (HCPT@SCL)-LDH was modified using polyethylene glycol (PEG) and carboxymethylcellulose (CMC), respectively. The results showed that the dispersity ::H:of:H:: nanohybrids was obviously improved, and PEG worked better than CMC. The PEG-(HCPT@SCL)-LDH had favorable dispersity with average size ::H:of:H:: ca. 70 nm. PEG-(HCPT@SCL)-LDH showed well controlled release property and in vitro drug release kine-tics from the nanohybrids could be fitted with the pseudo-second-order kinetic model. The diffusion ::H:of:H:: HCPT through the LDH particles played an important role in controlling the drug release. ©, 2015, Higher Education Press. All right reserved.

卷号：36

期号：10

是否译文：否