Key Words:Hydroxyl camptothecin; Layered double hydroxide; Coassemble; Nanohybrid
Abstract:(Hydroxyl camptothecin@ sodium cholate) -layered double hydroxide (LDH) nanohybrids were prepared by a modified drug-coassembly method. Firstly, Hydroxyl camptothecin(HCPT) was incorporated into micelles derived from sodium cholate(SCL) which negatively charged. The negatively charged micelles intercalated HCPT@ SCL-LDH nanohybrids were prepared by a co-assembly between LDH nanosheets and sodium cholate micelles with the encapsulated HCPT could keep the biological active lactone form, and the drug loading of so-obtained nanohybrid was 12. 9%. (HCPT@ SCL) -LDH was modified using polyethylene glycol (PEG) and carboxymethylcellulose (CMC), respectively. The results showed that the dispersity of nanohybrids was obviously improved, and PEG worked better than CMC. The PEG-(HCPT@ SCL) -LDH had favorable dispersity with average size of ca. 70 nm. PEG-(HCPT@ SCL) -LDH showed well controlled release property and in vitro drug release kine-tics from the nanohybrids could be fitted with the pseudo-second-order kinetic model. The diffusion of HCPT through the LDH particles played an important role in controlling the drug release.
Volume:36
Issue:10
Translation or Not:no