包覆层厚度对Fe_3O_4@SiO_2核壳结构纳米粒子磁共振性能的影响

发布时间：2021-03-15 点击次数：

• 关键字：Antifouling biosensor; Peptide; Electrochemistry; PEDOT; Cancer biomarker; DNA
• 摘要：Zwitterionic peptides were anchored to a conducting polymer of citrate doped poly(3,4-ethylenedioxythiophene) (PEDOT) via the nickel cation coordination, and the obtained peptide modified PEDOT, with excellent antifouling ability and good conductivity, was further used for the immobilization of a DNA probe to construct an electrochemical biosensor for the breast cancer marker BRCA1. The DNA biosensor was highly sensitive (with detection limit of 0.03 fM) and selective, and it was able to detect BRCA1 in 5% (v/v) human plasma with satisfying accuracy and low fouling. The marriage of antifouling and biocompatible peptides with conducting polymers opened a new avenue to construct electrochemical biosensors capable of assaying targets in complex biological media with high sensitivity and without biofouling.
• 卷号：92
• 是否译文：否