Mixed Self-Assembled Aptamer and Newly Designed Zwitterionic Peptide as Antifouling Biosensing Interface for Electrochemical Detection of alpha-Fetoprotein

发布时间：2021-03-15 点击次数：

• 关键字：mixed self-assembly; antifouling; zwitterionic peptide; aptamer; alpha-fetoprotein; electrochemical biosensor
• 摘要：A sensitive and low-fouling aptasensor for alpha-fetoprotein (AFP) was developed based on mixed self assembled aptamers and newly designed zwitterionic peptides, where densely immobilized peptides formed an antifouling layer to resist nonspecific protein adsorption, and sparsely attached aptamers acted as the recognizing layer to achieve target binding. The obtained biosensing interface responded to the target AFP with a strikingly selective and sensitive manner, exhibited excellent protein-resistant performance even in complex human serum solution, and showed promising feasibility for the quantitative analysis of AFP in real human serum samples.
• 卷号：2
• 期号：4
• 是否译文：否