Key Words:PEROXIDE

Abstract:Chemodynamic therapy (CDT) employs Fenton catalysts to kill bacteria by converting hydrogen peroxide (H2O2) into toxic hydroxyl radical ( center dot OH). Among them, Fenton-type metal peroxide nanoparticles fasci-nate nanomaterials with intriguing physiochemical properties, but research on this antibacterial agent is still in its infancy. Herein, a distinct CuO2/TiO2 heterostructure constituted of ultrasmall copper per-oxide (CuO2) nanoclusters and sonosensitized ultrathin oxygen vacancy-rich porous titanium oxide (OV-TiO2) nanosheets was developed and was incorporated into microneedles for bilaterally augmented sono-chemodynamic and sonothermal antibacterial therapy. Engineering CuO2 nanoclusters on the surface of TiO2 nanosheets not only endows the Fenton catalytic activity for sono-chemodynamic therapy (SCDT), but also improves the sonodynamic and sonothermal performance of TiO2 by narrowing the bandgap of TiO2 and suppressing the recombination of electron-hole pairs. The high efficacy of this CuO2/TiO2 in-tegrated microneedle (CTMN) patch was systematically demonstrated both in vitro and in vivo with the eliminating rate > 99.9999% against multidrug resistant (MDR) pathogens in 5 min as well as accelerated wound tissue healing. This work highlights a promisingly new and efficient strategy for the development of sonosensitive and chemoreactive nanomedicine for non-antibiotic therapies.Statement of significance Feton-type metal peroxides, a novel nanomaterial with self-supplied oxygen and hydrogen peroxide, can achieve effective antimicrobial activity in vitro. However, there is a lack of effective nanomaterial delivery systems and suitable means for in vivo activation/enhancement of antimicrobial activity during bacterial infected skin wound treatment. In this study, we designed and prepared efficient ultrasound activable mi-croneedles that effectively addressed the deficiencies mentioned above and established a new paradigm for efficient utilization of metal peroxide nanomaterials and ultrasound based strategies. Noticeably, cop-per peroxide nanoclusters/oxygen vacancy-rich porous titanium oxide nanosheets (CuO2 /TiO2) integrated microneedle (CTMN) patch combines advantages of both sono-chemodynamic and sonothermal antibac-terial therapy, achieving one of the most instant and effective antibacterial efficacy ( > 99.9999% in 5 min) in vivo reported till now.(c) 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Volume:158

Issue:

Translation or Not:no