CN

朱之灵

Supervisor of Master's Candidates

Education Level:博士研究生

Degree:理学博士

Discipline:Material Physics and Chemistry

Paper Publications

Pomegranate-Like CuO2@SiO2 Nanospheres as H2O2 Self-Supplying and Robust Oxygen Generators for Enhanced Antibacterial Activity

Release time:2023-10-19 Hits:

Key Words:H2O2 self-supplying; oxygen generator; fenton-like reaction; reactive oxygen species; antibacterial

Abstract:Reactive oxygen species (ROS)-induced nanosystems represent one of the most essential, efficient, and encouraging nanobactericides for eliminating bacterial infection concerning the increasing resistance threats of existing antibiotics. Among them, Fenton-type metal peroxide nanoparticles are exciting nanomaterials with intriguing physiochemical properties, yet the study of this antimicrobial agent is still in its infancy. Herein, a robust pH-responsive Fenton nanosystem is constructed by the assembly of copper peroxide nanodots in pomegranate-like mesoporous silica nanoshells (CuO2@SiO2) that are capable of self-supplying H2O2 and sustainably generating O2. The enhanced antimicrobial performance is attributed to the pH responsiveness and excellent Fenton catalytic activity through either the Cu2+-catalyzed conversion of H2O2 to detrimental ROS under acid treatment or in situ O2 evolution in neutral media. Moreover, in vitro and in vivo investigations demonstrate that this nanocomposite can exhibit boosted antimicrobial capabilities and can significantly accelerate skin wound closure, while retaining outstanding cytocompatibility and hemocompatibility. Given its excellent physicochemical and antimicrobial properties, the broad application of this nanocomposite in bacteria-associated wound management is anticipated.

Volume:13

Issue:19

Translation or Not:no

Click:times | The Founding Time:.. | The Last Update Time:..

Laoshan Campus-99 Songling Road, Qingdao City, Shandong Province
Sifang Campus-No.53 Zhengzhou Road, Qingdao City, Shandong Province
Sino-German International Cooperation Zone (Sino-German Campus)-No. 3698 Tuanjie Road, West Coast New District, Qingdao City, Shandong Province
Gaomi Campus-No. 1 Xingtan West Street, Gaomi City, Shandong Province
Jinan Campus-No. 80 Wenhua East Road, Jinan City, Shandong Province ©2015 Qingdao University of Science and Technology
Administrator email: master@qust.e