CN

周现锋

Professor

Supervisor of Doctorate Candidates

E-Mail:

Education Level:博士研究生

Degree:理学博士

Discipline:Polymer Chemistry and Physics
Material Physics and Chemistry

Paper Publications

A water-soluble two-dimensional supramolecular organic framework with aggregation-induced emission for DNA affinity and live-cell imaging

Release time:2021-03-15 Hits:

Abstract:A water-soluble two-dimensional supramolecular organic framework (2D SOF) was prepared via selfassembly of cucurbit[8] uril (CB[8]) and a three-arm flat linker molecule, which contains a benzene ring as the core and three Brooker's merocyanine (BM) analogs as arms. The strong host-guest interactions between BM and CB[8] and the directional head-to-tail stacking modes between the BM arms synergistically led to the formation of a 2D SOF. The structure of the 2D SOF was verified by 1H NMR, 2D 1H NMR NOESY, and DLS characterizations, while the monolayer structure was characterized by Cryo-TEM and AFM measurements. The 2D SOF exhibited an obvious AIE enhancement effect in H2O. In addition, DNA induced photoluminescence enhancement was observed for the monomer. As a result, this AIEgen-based 2D SOF could feature not only as a cell visualizer but also as a tracker for the nucleus in biological imaging due to the dynamic assembly process.

Volume:7

Issue:9

Translation or Not:no

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