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教师拼音名称:zhanglei

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Fluorescent alginate fiber with super-strong and super-tough mechanical performances for biomedical applications

关键字:CELLULOSE; CONFLICTS; STRENGTH; DESIGN

摘要:Emerging research attentions are focused on the development of fluorescent biomaterials for ious biomedical applications, including fluorescence-guided surgery. However, it is still challenging to prepare biomolecules-based fluorescent fibers with both satisfactory biocompatibility and optimal mechanical properties. Here, we develop a fluorescent robust biofiber through using a tetraphenylethene-containing surfactant as the contact points between polysaccharide chains of alginate. This newly developed contact points not only strengthen the cross-linking network of polysaccharide chains, but also afford enough energy-dissipating slippage for polysaccharide chains. Consequently, the generated fluorescent fiber is endowed with highly improved mechanical performances from plastic strain stage. The experimental results indicate that the fluorescent fiber shows good mechanical properties of breaking strength of 1.10 GPa (12.09 cN/dtex), Young's modulus of 39.81 GPa and toughness of 137.26 MJ/m(3), which are comparable to those of dragline silk and outperforming spider silk proteins and other artificial materials. More importantly, its satisfactory biosafety and wound healing-promoting ability as a fluorescent suture are solidly proved by both in vitro and in vivo assays, which opens an opportunity for its biological and biomedical applications. This study provides a novel strategy for the development of robust fluorescent biomaterials.

卷号:347

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崂山校区 - 山东省青岛市松岭路99号   
四方校区 - 山东省青岛市郑州路53号   
中德国际合作区(中德校区) - 山东省青岛市西海岸新区团结路3698号
高密校区 - 山东省高密市杏坛西街1号   
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