Key Words:BATCH COOLING CRYSTALLIZATION; NEAR-INFRARED SPECTROSCOPY; ATR-FTIR SPECTROSCOPY; IN-SITU RAMAN; MEDIATED POLYMORPHIC TRANSFORMATION; VARIABLE SELECTION METHODS; MULTIVARIATE DATA-ANALYSIS; SOFT SHRINKAGE APPROACH; METASTABLE ZONE WIDTH; NIR SPECTROSCOPY

Abstract:Measuring the solution concentration of processes for product quality control in industrial crystallization processes is a hot topic. In recent years, with the development of process analysis technology, various innovative measurement technologies for different situations and operating conditions have been developed. This paper systematically reviews the research on various solution concentration measurement technologies that have been developed for the crystallization process. These measurement technologies are divided into off-line, at-line, online, and in-situ methods based on their measurement modes and principles. The measurement principle, advantages, disadvantages, application field, and development status of each of the existing measurement technologies are illustrated in detail, with a particular focus on measurement methods based on spectroscopy technology, which are very popular for crystallization processes. In addition, this paper presents the problems of solution concentration measurement technology and points out future research directions.

Volume:187

Issue:文献号110328

Translation or Not:no