基于TRIZ的油气储运工程专业学生创新与实践能力培养
关键字：Targeted drugs delivery; Cancer cell; Gold nanorods; Functional aptamer; Doxorubicin
摘要：Double functional aptamer switch probes based on gold nanorods (GNR) was developed for targeted cancer treatment. In order to specifically recognizing the target cell, functional Romas-aptamer was assembled on GNRs. The conformation-dependent fluorescence turn-on properties of the functional Romas-aptamer provided an opportunity to utilize the conformational conversion of the sequence as a valuable motif for stimuli-responsive cell-sensors. Meanwhile, multiple GC-pair sequences into ATP-aptamer dsDNA were to enhance loading capacity of the drug doxorubicin (DOX). Combining the capabilities of two functional aptamers, intracellular ATP was detected and molecular drug was transported into target cell for therapeutic efficacy. This strategy was studied both in vitro and in vivo. (C) 2016 Elsevier B.V. All rights reserved.
卷号：235
期号：
是否译文：否
