Key Words:Shells (structures);Biocompatibility - Drug delivery - Iron oxides - Magnetite - Microspheres - Nanostructures - Superparamagnetism;Core shell nano structures - Enhanced efficiency - External magnetic field - Fe3O4 nanoparticles - Fe3O4 supraparticles - Mil 100(Fe) - Step-by-step method - Superparamagnetics

Abstract:Superparamagnetic Fe<inf>3</inf>O<inf>4</inf>supraparticles@MIL-100(Fe) core-shell nanostructure microspheres were successfully constructed by a facile step-by-step method. The polyacrylate formed in situ during the process of the preparation of Fe<inf>3</inf>O<inf>4</inf>supraparticles not only acted as a stabilizer on the Fe<inf>3</inf>O<inf>4</inf>nanoparticles surface, but also played a crucial role as a "bridge" in the initial stage of the framework components selectively assembly on the Fe<inf>3</inf>O<inf>4</inf>supraparticle surfaces. The structure and composition of the obtained microspheres were characterized by SEM, TEM, DLS, XRD, FTIR, and TG analysis. The MPMS results revealed that the introduction of the MOF shells can inhibit the interplay among the neighboring Fe<inf>3</inf>O<inf>4</inf>supraparticles while an external magnetic field applied. The well-dispersed microspheres are biocompatible, which endow the microspheres great potential in drug targeting applications with enhanced efficiency.<br/> © 2015 Elsevier Inc.

Volume:461

Issue:期

Translation or Not:no