王鲲鹏

副教授

副教授 硕士生导师

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学历:博士研究生

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Simple cyclic chalcone dye with multiple optical functions: Piezochromism and lysosomes staining

发布时间:2024-12-23 点击次数:

关键字:FLUORESCENT-PROBES; INDUCED EMISSION
摘要:Both artificially synthesized and naturally occurring cyclic chalcones have been widely studied for their excellent biological activities. However, research on its photophysical properties is still limited. In the present study, we designed and synthesized a small molecule fluorescent dye based on the ICT effect, using dimethylamino as the electron-donating group and carbonyl as the electron withdrawing group, and investigated its photophysical properties in depth. Although YB is a simple small molecule, it exhibits significant piezochromic properties. The fluorescence of YB can change from green to yellow through grinding. After solvent fumigation, the fluorescence reverts to green. Furthermore, YB was used successfully in the lysosomal targeting. This study expands the research on the photophysical properties of cyclic chalcone and give richness to application of cyclic chalcone compounds.
卷号:318
期号:
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