王鲲鹏   Associate professor

No content

Dimethylamino naphthalene-based fluorescent probes for hydrogen sulfide detection and living cell imaging

Release time:2023-10-19  Hits:

  • Key Words:Hydrogen sulfide;Cytology - Fluorescence - Naphthalene - Probes - Spectrum analysis - Sulfur compounds - Sulfur determination
  • Abstract:Hydrogen sulfide shows great importance in various physiological and biochemical processes. The development of fluorescence probes for facile and efficient detection of H<inf>2</inf>S has attracted increasing attention of researchers. Herein, we synthesized two fluorescence probes based on simple naphthalene structure for detection of H<inf>2</inf>S. Upon reaction with H<inf>2</inf>S, the probe DN-DM exhibited a red fluorescence emission with large Stokes shift. The probe showed high sensitivity, pH insensitivity and good selectivity for H<inf>2</inf>S over other analytes including common biothiols. The detection mechanism was based on the thiolysis of the dinitrophenyl ether moiety, which was confirmed by <sup>1</sup>H NMR spectral analysis. The DFT calculation was also performed for a deeper understanding of the photophysical properties. In addition, these probes showed good cell-membrane permeability and could be utilized for detection of H<inf>2</inf>S in living cells.<br/> © 2019
  • Volume:228
  • Issue:*
  • Translation or Not:no