副教授
硕士生导师
教师拼音名称:pangxiujiang
入职时间:2005-05-10
所在单位:物理化学教研室
学历:博士研究生
性别:女
学位:工学博士
职称:副教授
最后更新时间:..
关键字:Layered double hydroxides; 10-Hydroxycamptothecin; Sebacate; Secondary intercalation
摘要:10-Hydroxycamptothecin (HCPT) as a hydrophobic anticancer drug brings many challenges in the clinical applications due to its poor water solubility and the presence of a chemically unstable lactone ring. In this work, the nanocomposites of HCPT intercalated layered double hydroxide (LDH) were prepared by a secondary intercalation method, and the encapsulated HCPT could keep the biologically active lactone form. A Zn-Al-NO3 LDH was pillared with sebacate anions by a co-precipitation method in an aqueous medium, and then HCPT was intercalated into the LDH's gallery via hydrophobic interaction in an ethanol medium. The parallel alkyl chains of perpendicularly arranged sebacate anions in the LDH gallery provide a hydrophobic space for the drug intercalation. The in vitro release kinetics of HCPT from the nanocomposites could be fitted with the pseudo-second-order kinetic model, and the diffusion of HCPT through the LDH particles played an important role in controlling the drug release. The nanocomposites can be considered as a potential drug delivery system. (c) 2012 Elsevier Masson SAS. All rights reserved.
卷号:16
是否译文:否