Photoelectrochemical cell enhanced by ternary heterostructured photoanode: Toward high-performance self-powered cathodic cytosensing

发布时间：2021-03-15 点击次数：

• 关键字：Cell signaling;Cells - Cytology - Molecular biology - Photoelectrochemical cells
• 摘要：Previously reported photoelectrochemical (PEC)cytosensing commonly relied on the use of photoelectrodes as both signaling sources and platforms to accommodate the biorecognition events. In such a design, the side reaction between photoelectrodes and potential reductive species in the biological media as well as the interplay between the photoelectrodes and biomolecules will inevitably impair the performance of the corresponding PEC cytosensors. Herein, we presented a facile and efficient PEC cytosensor by separating capture probe from the photoelectrode. The system is operated upon by using a ternary heterostructured photoanode to provide an evident and stable photocurrent signal, an aptamer-based biocathode for recognizing and capturing the target cells, and the corresponding signal reduction from the cell-induced steric hindrance effect. Exemplified by human breast cancer cells (MCF-7), the proposed system realizes the separation of the signaling photoanode and the sensing biocathode toward a sensitive and selective self-powered PEC MCF-7 cytosensor. This work reports a new PEC cytosensing protocol, and it is expected to attract more interest in the research of high-performance PEC cytosensing. ? 2019 Elsevier B.V.
• 卷号：137
• 期号：*
• 是否译文：否