中文

防风抑尘网开孔形式对流场的影响

Hits:

  • Key Words:STRATEGIES

  • Abstract:Designing effective biosensing interfaces requires robust biomolecule immobilization strategies. Traditional goldsulfur bonds (Au-S) have low affinity and are prone to ligand substitution reactions in complex biological environments. In this study, we introduce an innovative approach utilizing a trifunctional branched-cyclopeptide (TBCP) for self-assembly onto platinum nanoparticles (PtNP)-modified electrodes. TBCP immobilization on PtNP via Pt-S interaction proves significantly more stable than Au-S bonding. In addition, TBCP peptides assembled through Pt-S interactions exhibit low susceptibility to displacement by small molecules like glutathione, making them ideal for constructing robust biosensors with high stability in biological fluids. Leveraging peptide multifunctionality and strong Pt-S interactions, TBCP-modified electrodes excel in ious biological fluids, detecting the breast cancer marker ErbB2 in human serum. The high sensitivity of the TBCP/PtNP-based biosensor distinguishes serum samples from breast cancer patients and healthy individuals. This self-assembly strategy represents a promising advance in constructing biosensors with robust operation in complex biological media.

  • Volume:418

  • Issue:-

  • Translation or Not:no


Laoshan Campus-99 Songling Road, Qingdao City, Shandong Province
Sifang Campus-No.53 Zhengzhou Road, Qingdao City, Shandong Province
Sino-German International Cooperation Zone (Sino-German Campus)-No. 3698 Tuanjie Road, West Coast New District, Qingdao City, Shandong Province
Gaomi Campus-No. 1 Xingtan West Street, Gaomi City, Shandong Province
Jinan Campus-No. 80 Wenhua East Road, Jinan City, Shandong Province ©2015 Qingdao University of Science and Technology
Administrator email: master@qust.e
Click:
  MOBILE Version

The Last Update Time:..