A label-free electrochemical immunosensor based on rhombic dodecahedral Cu<inf>3</inf>Pt nanoframes with advanced oxygen reduction performance for highly sensitive alpha-fetoprotein detection

Key Words:Platinum alloys;Binary alloys - Chlorine compounds - Copper alloys - Electrolytic reduction - Immunosensors - Oxygen

Abstract:Herein, rhombic dodecahedral Cu<inf>3</inf>Pt nanoframes (Cu<inf>3</inf>Pt NFs) were prepared via solvothermal strategy using theobromine as the reductant and structure-directing agent, coupled with cetyltrimethylammonium chloride (CTAC) as the co-structure-director. The samples showed dramatically boosted catalytic performance for oxygen reduction reaction (ORR), owing to their highly open structures with enlarged specific surface areas. Using Cu<inf>3</inf>Pt NFs catalyzed ORR as signal amplification platform, a novel electrochemical immunosensor was constructed to monitor alpha-fetoprotein (AFP). The as-fabricated immunosensor displayed a wide linear range of 0.1–10⁴ pg mL^–1 and a low detection limit of 0.033 pg mL^–1.<br/> © 2019 Elsevier B.V.

Volume:288

Issue:

Translation or Not:no