青岛科技大学主页平台管理系统 Liu Yongzhuo--Home-- A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

刘永卓

Education Level:博士研究生

Degree:工学博士

Discipline:Chemical Engineering

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A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

Release time:2021-03-15 Hits:

Key Words:FLUORESCENCE; NANOPARTICLES; PROBE; MITOCHONDRIA

Abstract:In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state. This theranostic molecule can be activated by nitroreductase under mild hypoxia to be used in fluorescence imaging and highly efficient photodynamic therapy (PDT) both in 2D and 3D (spheroids) HeLa cell culture models.

Volume:56

Issue:43

Translation or Not:no

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