青岛科技大学  English 
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教授 博士生导师  
硕士生导师  

教师拼音名称:linjianjian

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入职时间:2018-09-11

所在单位:化学与分子工程学院

学历:博士研究生

办公地点:四方校区第一实验楼216

性别:女

联系方式:19862229511

学位:工学博士

职称:教授

毕业院校:澳大利亚伍伦贡大学

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ZIF-8 based microspheres with ordered mesopores and dual responsive surfaces

关键字:DRUG-DELIVERY; NANOPARTICLES; FLUORESCENCE; FABRICATION

摘要:Zeolite imidazolate framework-8 (ZIF-8) is considered to be a potential drug delivery system for anticancer drugs. In order to address such challenges as its dosage limitation, toxicity, intelligent responsiveness, a ZIF-8 based biocompatible porous material of micron-size (ZIF-8 microphere/DOX@ PCM-PDA composites, ZMDPCs) is designed with ordered topology and dual responsive surfaces. The large specific surface area and hierarchical pores endow ZMDPCs with high loading capacity (1 mg could carry 3.8 mg DOX). The biocompatibility is enhanced by polydopamine (PDA) decoration. Moreover, PDA could be a photothermal converting material to trigger phase transition of PCM (as a thermal response valve) through NIR irradiation. Drug release could be controllable by stimulation of NIR or pH. With such biocompatibility, degradability and responsive surfaces, ZMDPCs show promising potential as a drug delivery vehicle.

卷号:38

期号:

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