博士生导师
硕士生导师
教师拼音名称：lidongxiang
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学历：博士研究生
学位：理学博士
毕业院校：山东大学
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关键字：DOUBLE HYDROXIDE NANOSHEETS; LAYERED DOUBLE HYDROXIDE; METAL-ORGANIC FRAMEWORKS; HYDROGEN-PEROXIDE; SENSING PLATFORM; GRAPHENE OXIDE; EFFICIENT; GROWTH; SENSOR; BIOSENSOR
摘要：The quantification of hydrogen peroxide (H2O2), a vital biomarker in pathogenesis released from live cells, is of importance to life science. This work presents a method to assemble gold nanoparticles (AuNPs) in core-shell zeolite imidazolate framework (ZIF) crystals by the direct growth of ZIF-67 on ZIF-8 seeds (AuNPs/ZIF-8@ZIF-67). With a large surface, abundant catalytic sites, enhanced conductivity, and good dispersity of components, the AuNPs/ZIF-8@ZIF-67-modified glassy carbon electrode (AuNPs/ZIF-8@ZIF-67/GCE) reveals excellent catalytic activity for the electrochemical reduction of H2O2. The modified electrode exhibits a wide linear range of 0.05-120 mu M and a low detection limit of 0.016 mu M (S/N = 3) with excellent selectivity, stability, and reproducibility. The corresponding electrochemical sensor has been successfully used for the practical detection of H2O2 released from living human embryonic kidney 293 (HEK293) cells and nonmetastatic breast cancer (MCF-7) cells under optimal conditions. This sensor demonstrates the potential for in situ detection applications in complicated biological systems.
卷号：11
期号：43
是否译文：否
