博士生导师
硕士生导师
教师拼音名称：lidongxiang
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学历：博士研究生
学位：理学博士
毕业院校：山东大学
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关键字：LAYERED DOUBLE HYDROXIDES; MECHANOCHEMICAL APPROACH; INTERCALATION
摘要：Spherical microspheres of methotrexate intercalated layered double hydroxides (MTX/LDHs) have been synthesized by the calcination-reconstruction method and using the carbon spheres as template. Here, the effect of carbon spheres' size on the morphology, drug-loading capacity and controlled-release property of the final product-MTX/LDHs nanohybrids are examined in details. It has been found out that the morphology of MTX/LDHs nanohybrids synthesized without template is irregular and aggregated seriously, while the MTX/LDHs nanohybrids prepared with the template of carbon spheres are spherical and monodispersed. With increasing in the size of carbon spheres, the particle size of MTX/LDHs is increasing gradually, and the morphology changes from irregular to the regular one. A set of characterization technologies including Zeta potentials, sustained-release performance and anticancer effect will be carried out to investigate the physical and chemical properties, and it's indicated that spherical MTX/LDHs have excellent controlled-release property and good anticancer effect. Therefore, this work provides a promising approach for the design and synthesis of spherical MTX/LDHs nanohybrids, which can be potentially applied in drug delivery devices.
卷号：42
期号：11
是否译文：否
