Poly(ethylene glycol) haired layered double hydroxides as biocompatible nanovehicles: Morphology and dispersity study

Key Words:Layered double hydroxides (LDHs); Poly(ethylene glycol); Surface grafting

Abstract:The surface modification of the layered double hydroxides (LDHs) is of much importance for the purposes of the nanoparticle stability, dispersity and biocompatibility. Herein, we reported the fabrication and dispersible properties of surface modified LDHs by poly(ethylene glycol) (PEG) derivatives. First, Mg-Al LDHs were incubated with sulfate or carboxylate-terminated poly(ethylene glycol) (PEG) to fabricate PEG haired LDHs. The pristine LDH particles were truncated into smooth pie-like disks and their Zeta potential reversed to a highly negative value after the surface modification. The obtained PEG/LDH nanocomposites displayed a highly enhanced stability and dispersity due to the polymer steric hindrance and the electrostatic repulse. The PEG haired LDHs might be considered as a multifunctional model vehicle in biodelivery applications in the next applications due to the biocompatible polymer shells. (C) 2011 Elsevier B.V. All rights reserved.

Volume:384

Issue:1-3

Translation or Not:no