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来曲唑-十二烷基硫酸钠-层状双金属氢氧化物纳米杂化物的合成及性能

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  • Key Words:层状双金属氢氧化物;;来曲唑;;二次组装法;;纳米杂化物

  • Abstract:采用二次组装法制备了来曲唑-十二烷基硫酸钠(SDS)-层状双金属氢氧化物(LDHs)纳米杂化物,并用XRD、FT-IR和TEM进行了表征,其载药量为10.1%。分别在pH4.8和7.2的介质中研究药物释放动力学表明,所制备的来曲唑-SDS-LDHs纳米杂化物具有明显的缓释效果,是具有发展潜力的新型药物控释体系。在pH=7.2的缓冲溶液中其释放速率明显低于pH=4.8的缓冲溶液,释放动力学过程符合准二级动力学方程。

  • Volume:v.31;No.126

  • Issue:05

  • Translation or Not:no

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