青岛科技大学  English 
李春芳
赞  

教师拼音名称:lichunfang

手机版

访问量:

最后更新时间:..

Hierarchical gold/copolymer nanostructures as hydrophobic nanotanks for drug encapsulation

关键字:

摘要:Various nanoparticles are used to fabricate innovative systems for drug encapsulation and cancer therapy. In this paper, the hierarchical core-shell nanostructures composed of gold nanoparticles and poly(dimethylsiloxane)-poly(ethylene glycol) (PDMS-PEG) block copolymers are fabricated via a hydrosilylation reaction. The obtained gold/copolymer nanocomposites display a desired amphiphilic property and can be well-dispersed in water when the PEG blocks are long enough. The hydrophobic drug hypocrellin B (HB) can be encapsulated into these water-dispersible nanocomposites based on the hydrophobic-hydrophobic interaction between HB molecules and PDMS segments. The gold/copolymer nanocomposites loaded with HB show a rational anticancer ability in the photodynamic therapy although the gold/copolymer nanocomposites without drug also have a little cytotoxicity. Such hierarchically structured core-shell nanocomposites can be considered as water-dispersible nanotanks for hydrophobic drugs in the development of multifunctional biodelivery systems.

卷号:20

期号:36

是否译文:

崂山校区 - 山东省青岛市松岭路99号   
四方校区 - 山东省青岛市郑州路53号   
中德国际合作区(中德校区) - 山东省青岛市西海岸新区团结路3698号
高密校区 - 山东省高密市杏坛西街1号   
济南校区 - 山东省济南市文化东路80号©2015 青岛科技大学    
管理员邮箱:master@qust.edu.cn