青岛科技大学  English 
李春芳
赞  

教师拼音名称:lichunfang

手机版

访问量:

最后更新时间:..

Self-assembled vesicles of amphiphilic poly(dimethylsiloxane)-b-poly (ethylene glycol) copolymers as nanotanks for hydrophobic drugs

关键字:Amphiphilic block copolymer; Self-assembly; Nanovesicles; Drug encapsulation

摘要:Polymeric nanovesicles self-assembled by amphiphilic block copolymers have attracted much attention in the biodelivery of hydrophobic drugs. In this paper, the amphiphilic copolymers of poly(dimethylsiloxane)-block-poly(ethylene glycol) (PDMS-b-PEG) were synthesized to fabricate polymeric nanovesicles in mixed solvent of THF and water. Dynamic light scattering (DLS) were used to monitor the assembling process of the block copolymers, and the aqueous nanovesicle solution could be obtained by a slow evaporation of THF. The vesicle size could be adjusted according to the volume ratio of water to THF and also the concentration of copolymers in the assembly. Higher water content in the mixed solvent produced smaller vesicles, while higher polymer concentration caused the formation of larger vesicles. The hydrophobic domain of the obtained nanovesicles could encapsulate hydrophobic drugs based on the hydrophobic interaction, in which the nanovesicles acted as water-soluble hydrophobic nanotanks. The drug encapsulation capability of these nanovesicles might exhibit a significant potential as drug nanocarriers in biodelivery system. (C) 2010 Elsevier B.V. All rights reserved.

卷号:372

期号:1-3

是否译文:

崂山校区 - 山东省青岛市松岭路99号   
四方校区 - 山东省青岛市郑州路53号   
中德国际合作区(中德校区) - 山东省青岛市西海岸新区团结路3698号
高密校区 - 山东省高密市杏坛西街1号   
济南校区 - 山东省济南市文化东路80号©2015 青岛科技大学    
管理员邮箱:master@qust.edu.cn