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Key Words:Carbosilane dendrimer; Fluorescence; Encapsulation; Probe molecule
Abstract:Amphiphilic dendritic macromolecules are suitable for the noncovalent encapsulation of guest molecules and could potentially be applied in drug-delivery systems. In this work, amphiphilic carbosilane dendrimers with peripheral poly(ethylene glycol) (PEG) units were synthesized using a hydrosilylation reaction, and their encapsulation properties were studied by fluorescence spectroscopy, using pyrene as the probe molecule. The results showed that the encapsulating capacity of the dendrimers increased as the number of PEG units increased, and that it also depended to some degree on the dendrimer generation.
Volume:20
Issue:8
Translation or Not:no