Controlled release competitive electrochemiluminescence sensor based on PbS QDs as novel quencher for ultrasensitive monitoring of environmental pollutant
关键字：FLUOROTELOMER ALCOHOLS; ENERGY-TRANSFER; QUANTUM DOTS; LUMINESCENCE; POLYMER; ARRAYS; MOFS
摘要：Per-and polyfluoroalkyl substances (PFAS), as a diverse group of synthetic chemicals, are resistant to degradation and have been proven to accumulate in the environment and the human body, potentially causing serious harm to health. Electrochemiluminescence (ECL), due to its advantages such as simple operation, high sensitivity and low background interference, is often used as a sensitive detection method. Therefore, a sensitive ECL method is beneficial to detection of PFAS. In order to realize this target, controlled release, competition and resonant energy transfer (RET) strategies were introduced into the sensing mechanism, endowing the sensor with distinct signal change. In this work, with SiO2 as the controlled release carrier and Au NPs-antigen as the blocking agent, PbS quantum dots (QDs) was released to respond biomolecular stimulation between the target and the related antibody. PbS, as an outstanding semiconductor material, shows controllable morphology, high optical absorption coefficient and carrier mobility. Accordingly, PbS QDs is considered to be able to better absorb the excitation energy of luminophore to realize RET in analysis, resulting in the descending signal. Combined with competition of antigen and standard substance, the significant signal decline was inversely proportional to the concentration of the target, improving the sensitivity of the sensor greatly. Based on these strategies, the constructed sensor exhibited excellent sensitivity and accuracy for target detection, with a wide linear range of 50 fg/mL to 1 mu g/mL and a low limit of detection (27.9 fg/mL). This work provided a feasible method for ultrasensitive monitoring of environmental pollutants in water.
卷号：518
期号：
是否译文：否
