Target-triggered dynamic hairpin assembly for signal amplification of microRNA and oncogenes and its application in live-cell imaging

Release time:2021-03-15 Hits:

Key Words:HYBRIDIZATION CHAIN-REACTION; DNA NANOTECHNOLOGY

Abstract:Based on target-triggered dynamic hairpin assembly (DHA) in both unidirectional and bilateral growth manners DNA nanobrushes are constructed, which realize sensitive and selective detection of short miRNA (miR-21) and long DNA (BRCA1), respectively. Moreover, the unidirectional DHA strategy is readily applied to in situ imaging of miR-21 in different live cells.

Volume:55

Issue:28

Translation or Not:no