青岛科技大学主页平台管理系统 chenkezheng--Home-- Novel synthesis of AB-type carbonated hydroxyapatite hierarchical microstructures with sustained drug delivery properties

陈克正

Professor

Supervisor of Doctorate Candidates

Supervisor of Master's Candidates

Date of Birth:1965-10-27

Team member

Paper Publications

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Novel synthesis of AB-type carbonated hydroxyapatite hierarchical microstructures with sustained drug delivery properties

Release time:2023-10-19 Hits:

Key Words:sheet-assembled hollow mic

Abstract:In this study, AB-type carbonated hydroxyapatite (CHAp) nanosheet-assembled hollow microstructures were rapidly synthesized via a hydrothermal process without sintering. Urea was employed as both a pH adjusting agent and a CO32- source during hydrothermal reaction. The influence of hydrothermal time on the final morphologies of the products was systematically investigated. The as-prepared CHAp hollow microstructures with a diameter of about 3-4 mu m consist of numerous radially oriented CHAp nanosheets as building units with an average thickness of about 10 nm. The morphology of the product can vary from a hollow microstructure to a solid dandelion-like structure with increasing hydrothermal time. Possible mechanisms for the formation of a nanosheet-assembled CHAp hollow microstructure and a solid dandelion-like microstructure in the presence of both urea and ethylenediaminetetraacetic acid (EDTA) are illustrated. Moreover, the as-prepared CHAp hollow microstructures exhibit a high drug loading capacity and sustained drug release properties.

Volume:18

Issue:41

Translation or Not:no

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