Supervisor of Doctorate Candidates
Supervisor of Master's Candidates
Date of Birth:1965-10-27
Paper Publications
Impact of metallic trace elements on relaxivities of iron-oxide contrast agents????(Open Access)
Key Words:Iron oxides;Body fluids - Deterioration - Harmonic analysis - Magnetite - Nanoparticles - Positive ions - Quantum theory - Trace elements
Abstract:In this work, well-defined 3 nm-sized Ca<sup>2+</sup>, Fe<sup>3+</sup>, Na<sup>+</sup>, Mg<sup>2+</sup>, Zn<sup>2+</sup>, Ni<sup>2+</sup>, Co<sup>2+</sup>, and Cd<sup>2+</sup> cation-adsorbed Fe<inf>3</inf>O<inf>4</inf>/γ-Fe<inf>2</inf>O<inf>3</inf> nanoparticles were used as prototype systems to investigate the influence of metallic trace elements in body fluids on the relaxivities of iron-oxide contrast agents. It was found that surface-adsorbed cations formed a deterioration layer to induce pronounced relaxivity loss. Theoretical study showed that such relaxivity loss can be well described by a modified GCAS function, taking into account the harmonic cation oscillations around Fe<inf>3</inf>O<inf>4</inf>/γ-Fe<inf>2</inf>O<inf>3</inf> nanoparticles. Quantum mechanics analyses revealed that even-parity and odd-parity states of harmonic oscillations are dominant in r<inf>1</inf> and r<inf>2</inf> relaxivities, respectively. Moreover, the harmonic oscillations of Na<sup>+</sup> and Mg<sup>2+</sup> cations around Fe<inf>3</inf>O<inf>4</inf>/γ-Fe<inf>2</inf>O<inf>3</inf> nanoparticles are found to be classical forbidden, which are quite different from their counterparts located in the classical permissive area.<br/> © 2019 The Royal Society of Chemistry.
Volume:9
Issue:53
Translation or Not:no