CN

陈克正

Professor

Supervisor of Doctorate Candidates

Supervisor of Master's Candidates

Date of Birth:1965-10-27

Paper Publications

氧化石墨烯的制备及其对盐酸多柔比星的高效装载和缓释性能

Release time:2021-03-15 Hits:

Key Words:氧化石墨烯;;制备;;载药;;缓释;;细胞毒性

Abstract:采用改进的酸氧化的方法制备氧化石墨,经超声处理得到氧化石墨烯。利用扫描电子显微镜、原子力显微镜对其形貌进行表征,并研究了其对盐酸多柔比星的装载和释放性能。结果表明:用改进的方法制备得到了厚度在0.897nm左右的单层氧化石墨烯,它对盐酸多柔比星的载药率较高,其释放具有较好的缓释性和pH依赖性。释放时间96h时,pH=5.8和pH=7.4条件下药物的累积释放率分别为96.90%和70.62%,体外细胞毒性实验证实氧化石墨烯作为潜在的药物载体具有安全性。

Volume:v.32;No.132

Issue:05

Translation or Not:no

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