青岛科技大学主页平台管理系统聂广明--中文主页-- An electrochemical immunosensor for the tumor marker alpha-fetoprotein using a glassy carbon electrode modified with a poly(5-formylindole), single-wall carbon nanotubes, and coated with gold nanoparticles and antibody

聂广明

教师拼音名称：N G M

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An electrochemical immunosensor for the tumor marker alpha-fetoprotein using a glassy carbon electrode modified with a poly(5-formylindole), single-wall carbon nanotubes, and coated with gold nanoparticles and antibody

关键字：5-Formylindole; Electrochemical polymerization; SWNTs; Nanocomposite; Biosensor

摘要：We report on a label-free electrochemical immunosensor for alpha-fetoprotein (alpha-FP). It is based on the use of a glassy carbon electrode that was first modified with conducting poly(5-formylindole) and single-walled carbon nanotubes (P5FIn/SWNTs), and then coated with gold nanoparticles and the respective antibody. The presence of aldehyde groups warrants direct immobilization of the antibody and results in a convenient method for fabricating of the immunosensor. Gold nanoparticles (GNPs) were deposited on the P5FIn/SWNTs composite material, and the modified electrode was applied to the detection of alpha-FP. The analytical signal is obtained by measuring the change of amperometric response at a typical working voltage of 100 mV before and after the immunoreaction. The detection limit is 200 fg mL(-1). The immunosensor is simple, sensitive, specific and reproducible. It has the potential for reliable point-of-care diagnosis of tumor or other diseases.

卷号：181

期号：13-14

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