Electrochemiluminescence biosensor for Ramos cells based on a nanostructured conducting polymer composite material (PICA-MWNTs)

Key Words:conducting polymers; indole; multiwalled carbon nanotubes; nanocomposites; sensors

Abstract:A novel nanostructured conducting polymer (PICA-MWNTs) is easily prepared by direct electrodeposition of indole-6-carboxylic acid (ICA) and carboxylic groups ended multiwalled carbon nanotubes (MWNTs) in acetonitrile in one step. The resulting PICA-MWNTs composites with larger specific surface area and quite a few functionalized carboxylic acid groups are naturally integrated as a continuous uniform film on the electrode. CdSe quantum dots electrochemiluminescence biosensor with high sensitivity for detection of Ramos cells is fabricated based on PICA-MWNTs. Coupled with nanoparticle-amplification technnique, this sensor shows high sensitivity and good selectivity for Ramos cells with a low detection limit of 390 cellsmL1. This result provides an avenue for a simple and sensitive approach for detection of Ramos cells, which may have great potential in clinical applications. (c) 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 23852392

Volume:51

Issue:11

Translation or Not:no